Local production of specific IgE antibody to house dust mite in nasal polyp tissues.
- Author:
Ji Won KANG
;
Dong Ho NAHM
;
Kyung Sik SUH
;
Hee Yeon KIM
;
Hae Sim PARK
- Publication Type:Original Article
- Keywords:
nasal polyp;
total IgE;
specific IgE;
house dust mite
- MeSH:
Antibodies;
Dust*;
Immunoglobulin E*;
Nasal Polyps*;
Pyroglyphidae*;
Skin;
United States National Aeronautics and Space Administration
- From:Journal of Asthma, Allergy and Clinical Immunology
1998;18(3):426-433
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: In order to confirm the local production of total and specific IgE antibodies in the nasal polyp tissues. MATERIAL AND METHOD: We measured total IgE and house dust mite(Dermatophagoides pteronpssinus .' DP)-specific IgE antibody using enzyme-linked immunosorbent assay(ELISA) in the supernatant of nasal polyp homogenates from 72 subjects undergoing nasal polypectomy. The subjects were divided into three groups according to skin reactivity to DP: 20 strongly atopic subjects to group I(mean wheal diameter) 3mm), 19 weakly atopic subjects to group II (mean wheal diameter 1-3mm) and 33 negative skin responders to group III. RESULT: Group I showed significantly higher levels of total and DP-specific IgE levels in the nasa
