Serum eosinophil cationic protein in patient with bronchial asthma ; comparison with other markers of disease activity.
- Author:
Ji Hoon YOO
;
Jae Sun CHOI
;
Chang Hyuk AHN
;
Byung Hoon LEE
;
Moon Jun NA
;
Jae Yul KIM
;
In Won PARK
;
Byung Whui CHOI
;
Sung Ho HUE
- Publication Type:Original Article
- Keywords:
Eosinophil cationic protein;
bronchial hyperresponsiveness;
bronchial obstruction;
bronchial asthma
- MeSH:
Asthma*;
Biomarkers;
Eosinophil Cationic Protein*;
Eosinophils;
Humans;
Immunoglobulin E;
Inflammation;
Inhalation;
Methacholine Chloride;
Spirometry
- From:Journal of Asthma, Allergy and Clinical Immunology
1998;18(3):466-472
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Serum eosinophil cationic protein(ECP) level has been proposed as a indirect marker of eosinophilic inflammation of the airway in bronchial asthma. OBJECTIVE: To evaluate serum ECP against indirect clinical markers of disease, we compared bronchial obstruction, bronchial hyperresponsiveness and peripheral blood eosinophil counts, total IgE with serum ECP levels in patients with bronchial asthma and normal controls. METHOD: Fourty-two patients with bronchial asthma and twenty-six normal controls were enrolled. Measurement were made by spirometry, inhalation challenge with methacholine, peripheral blood eosinophil counts, total IgE and FEIA(fluoroenzymatic immunoassay) of serum ECP RESULT: Serum ECP levels were significantly higher in asthmatic patients than normal controls(p<0.0,5). Serum ECP levels were correlated with peripheral blood eosinophil counts(p<0.01, r=0.544) and bronchial hyperresponsiveness(PC,)(p<0.01, r=-0.456) in patients with bronchial asthma. Serum ECP levels were correlated with degree of bronchial obstruction(FEV, % to predicted value, FEV1/FVC%) in total subjects, but not in asthmatic patients. CONCLUSION: Serum ECP level may be used as indicator of disease activity in bronchial asthma and be helpful in differentiation between normal person and asthmatic patients on simple serological method. Further studies on the changes of serum ECP levels according to disease course and therapeutic responses are needed.
