The Ability of FDG Uptake Ratio and Glut-1 Expression to Predict Mediastinal Lymph Node Metastasis in Resected Non-small Cell Lung Cancer.
- Author:
Sukki CHO
1
;
Eung Bae LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, Korea. skcho@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Positron emission tomography (PET);
Lung neoplasm;
Mediastinal lymph node;
Neoplasm marker
- MeSH:
Carcinoma, Non-Small-Cell Lung;
Humans;
Lung Diseases;
Lung Neoplasms;
Lymph Nodes;
Neoplasm Metastasis;
Tuberculosis, Pulmonary
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2010;43(5):506-512
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was designed to evaluate the FDG uptake ratio of mediastinal node and primary tumors using integrated PET/CT imaging combined with Glut-1 expression of the primary tumor in order to predict the N2 status more accurately in NSCLC patients. MATERIAL AND METHOD: Patients who underwent integrated PET/CT scanning with a detectable mSUV for both primary tumors and mediastinal lymph nodes were eligible for this study. The FDG uptake ratio between the mediastinal node and the primary tumor was calculated. RESULT: The average mSUV of primary tumors and mediastinal nodes were, respectively, 7.4+/-2.2 and 4.2+/-2.2 in N2-positive patients and 7.6+/-3.7 and 2.8+/-6.9 in N2-negative patients. The mean FDG uptake ratio of mediastinal node to primary tumor were 0.58+/-0.23 for malignant N2 lymph nodes and 0.45+/-0.20 for benign lymph nodes (p<0.05). Models which combined Glut-1 expression with an FDG ratio have better diagnostic power than models that use the FDG uptake ratio alone. CONCLUSION: In some patients with a previous history of pulmonary tuberculosis or other inflammatory lung diseases, an FDG uptake ratio combined with Glut-1 expression may be useful in diagnosing mediastinal node metastasis more exactly.
