Bone regeneration capacity of two different macroporous biphasic calcium materials in rabbit calvarial defect.
10.5051/jkape.2009.39.S.223
- Author:
Jung Chul PARK
1
;
Hyun Chang LIM
;
Joo Yeon SOHN
;
Jeong Ho YUN
;
Ui Won JUNG
;
Chang Sung KIM
;
Kyoo Sung CHO
;
Chong Kwan KIM
;
Seong Ho CHOI
Author Information
1. Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Korea. shchoi726@yuhs.ac
- Publication Type:Original Article
- Keywords:
bone substitutes;
hydroxyapatite wound healing
- MeSH:
Animals;
Apatites;
Bone Regeneration;
Bone Substitutes;
Calcium;
Calcium Phosphates;
Durapatite;
Humans;
Hydroxyapatites;
Male;
New Zealand;
Osteogenesis;
Rabbits
- From:The Journal of the Korean Academy of Periodontology
2009;39(Suppl):223-230
- CountryRepublic of Korea
- Language:English
-
Abstract:
ABSTRACT PURPOSE: Synthetic bone products such as biphasic calcium phosphate (BCP) are mixtures of hydroxyapatite (HA) and a- tricalcium phosphate (a- TCP). In periodontal therapies and implant treatments, BCP provides to be a good bone reconstructive material since it has a similar chemical composition to biological bone apatites. The purpose of this study was to compare bone regeneration capacity of two commercially available BCP. METHODS: Calvarial defects were prepared in sixteen 9-20 months old New Zealand White male rabbits. BCP with HA and a- TCP (70:30) and BCP with Silicon-substituted hydroxyapatite (Si-HA) and a-TCP (60:40) particles were filled in each defect. Control defects were filled with only blood clots. Animals were sacrificed at 4 and 8 week postoperatively. Histomorphometric analysis was performed. RESULTS: BCP with HAand a- TCP 8 weeks group and BCP with Si-HA and a- TCP 4 and 8 weeks groups showed statistically significant in crease (P<0.05) in augmented area than control group. Newly formed bone area after 4 and 8 weeks was similar among all the groups. Residual materials were slightly more evident in BCP with HA and a- TCP 8 weeks group. CONCLUSIONS: Based on histological results, BCP with HA and a- TCP and BCP with Si-HA and a- TCP appears to demonstrate acceptable space maintaining capacity and elicit significant new bone formation when compared to natural bone healing in 4 and 8 week periods.
