Cytomegalovirus as a Cause of Recurrent Anterior Uveitis in Immunocompetent Patients.
10.3341/jkos.2010.51.9.1245
- Author:
Jihyun PARK
1
;
Jae Lim CHUNG
;
Sung Ho LEE
;
Young Jae HONG
Author Information
1. Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea. jlchung@kimeye.com
- Publication Type:Original Article
- Keywords:
Cytomegalovirus;
Polymerase chain reaction;
Recurrent hypertensive anterior uveitis
- MeSH:
Antiviral Agents;
Aqueous Humor;
Cytomegalovirus;
Eye;
Herpes Simplex;
Herpesvirus 1, Human;
Herpesvirus 3, Human;
Humans;
Male;
Methylmethacrylates;
Polymerase Chain Reaction;
Polystyrenes;
Pyridines;
Thiazoles;
Toxoplasma;
Uveitis;
Uveitis, Anterior
- From:Journal of the Korean Ophthalmological Society
2010;51(9):1245-1249
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aimed to identify various infectious causes in unilateral recurrent hypertensive anterior uveitis in immunocompetent individuals. METHODS: Twenty eyes of 20 patients diagnosed with recurrent hypertensive anterior uveitis, who had negative systemic uveitis lab results, were enrolled. Polymerase chain reaction (PCR) was performed in the aqueous humor and peripheral blood specimens to detect the following infectious agents: cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), varicella zoster virus (VZV), toxoplasma. RESULTS: The mean age of 20 patients was 41.8 +/- 15.9 year (19-77 year), and 14 (70%) patients were male. CMV was positive in 7 eyes (35%) and was detected only in aqueous humor. HSV-1 was positive in 5 (25%) eyes; only in aqueous humor in 2 eyes, only in blood in 1 eye, and in both specimens in 2 eyes. Only 1 (5%) eye was positive for toxoplasma in the aqueous humor. CONCLUSIONS: This study demonstrated that CMV might be another major infectious cause in recurrent hypertensive anterior uveitis in immunocompetent patients. If CMV is detected, it might be reasonable to add appropriate antiviral agents, rather than treating only with immunosuppresive and hypotensive drugs.
