The annexin II expression in invasive cervical cancer.
- Author:
Hye Sung MOON
1
;
Yu Sun LEE
;
Hye Won CHUNG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea. mhsmhs@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Cervical cancer;
Annexin II
- MeSH:
Annexin A2*;
Biomarkers;
Blotting, Western;
Carcinogenesis;
Cervical Intraepithelial Neoplasia;
Cervix Uteri;
Female;
Humans;
RNA, Messenger;
Uterine Cervical Neoplasms*
- From:Korean Journal of Gynecologic Oncology
2007;18(1):8-16
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to determine annexin II expression in cervical cancer. METHODS: In Ewha Womans University Mokdong Hospital, normal and cervical cancer tissues were obtained from healthy women (n=11), from patients with cervical intraepithelial neoplasia (CIN, n=11) and from patients with cervical cancer (n=33). The expressions of annexin II mRNA and protein were examined by quantitative competitive-PCR and by western blot analysis. Annexin II mRNA and protein expressions were examined with repects to the clinical characteristics including tumor sizes and cancer stages. RESULTS: The expression of annexin II mRNA in cervical cancer was higher than that in the normal cervix, and CIN (p<0.05). Annexin II mRNA expression was not correlated with cervical cancer stage, or size of the tumor (p>0.05). The expression of annexin II protein in cervical cancer was higher than that in CIN but its expression was decreased according to the cervical cancer stage. CONCLUSION: Our results suggest that overexpression of annexin II mRNA and protein may be a biologic marker of cervical carcinogenesis.
