SoxD Transcription Factors: Multifaceted Players of Neural Development.
- Author:
Eun Hye JI
1
;
Jaesang KIM
Author Information
- Publication Type:Review
- Keywords: SoxD; Sox5; Sox6; Sox13; Neural stem cell; Neural development
- MeSH: DNA; Embryonic Development; Female; Leucine Zippers; Nervous System; Neural Stem Cells; Neurons; Oligodendroglia; Pregnancy; SOXD Transcription Factors*; Transcription Factors
- From:International Journal of Stem Cells 2016;9(1):3-8
- CountryRepublic of Korea
- Language:English
- Abstract: SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter- specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.
