Chronic Cyclophosphamide Induced Cystitis that is Improved by Mesna.
- Author:
Wonhee WOO
1
;
Changug LEE
;
Sungsu KIM
;
Ojung KWON
;
Seunghyun AHN
;
Bongmo SEONG
Author Information
1. Department of Urology, Hanil General Hospital, Seoul, Korea. wwhkjy@hanafos.com
- Publication Type:Case Report
- Keywords:
Mesna;
Cyclophosphamide;
Cystitis
- MeSH:
Acrolein;
Cyclophosphamide*;
Cystitis*;
Female;
Humans;
Mesna*;
Middle Aged;
Sodium
- From:Korean Journal of Urology
2005;46(4):420-421
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cyclophosphamide is alkylating agent used in the treatment of various solid tumors. Mucosal irritation by acrolein, the metabolite of cyclophosphamide, is believed to cause various symptoms of cystitis. The thiol compound, sodium 2-mercaptoethane sulfonate (Mesna), has been found to inactivate acrolein. We present an unusual case of a 64-year-old woman, who was treated as chronic cystitis. Her symptoms did not improve, so she was treated with Mesna under the assumption of cyclophosphamide induced cystitis; her symptoms then improved.
