Sustained Expression of Neuritin mRNA After Repeated Electroconvulsive Stimulations in the Rat Hippocampal Formation.
- Author:
Kun Woo PARK
1
;
Il Hwan KIM
;
Woong SUN
;
Hyun KIM
Author Information
- Publication Type:Original Article
- Keywords: neuritin; elctroconvulsive seizure (ECS); neuronal plasticity; dentate gyrus
- MeSH: Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Hippocampus; Neuronal Plasticity; Plastics; Rats; RNA, Messenger; Seizures
- From:Experimental Neurobiology 2009;18(1):62-65
- CountryRepublic of Korea
- Language:English
- Abstract: In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1xECS) or repeated elctroconvulsive seizures (8xECS) treatments to the rat. The expression of neuritin mRNA was transiently increased, and returned to basal level within 12 hours after 1xECS. Whereas initial induction of neuritin mRNA was similarly seen, these increased mRNA level was maintained for 24 hours in 8xECS group. In contrast, induction profile of BDNF was similar following 1x and 8xECS. These results suggest that regulation of neuritin expression may be plastically changed by repeated ECS treatment.
