Relationship Between Serum Uric Acid Levels, Metabolic Syndrome, and Arterial Stiffness in Korean.
10.4070/kcj.2010.40.7.314
- Author:
Ji Hyon LIM
1
;
Young Kwon KIM
;
Yong Seok KIM
;
Sang Hoon NA
;
Moo Yong RHEE
;
Myoung Mook LEE
Author Information
1. Department of Internal Medicine, Dongguk University College of Medicine, Ilsan Hospital, Goyang, Korea. ykkim@duih.org
- Publication Type:Original Article
- Keywords:
Uric acid;
Metabolic syndrome
- MeSH:
Adult;
Atherosclerosis;
Cardiovascular Diseases;
Cholesterol;
Creatinine;
Dyslipidemias;
Electrolytes;
Female;
Humans;
Hypertension;
Male;
Obesity, Abdominal;
Odds Ratio;
Pulse Wave Analysis;
Smoke;
Smoking;
Uric Acid;
Vascular Stiffness;
Waist Circumference
- From:Korean Circulation Journal
2010;40(7):314-320
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Associations have been reported between the serum uric acid (SUA) level, metabolic syndrome (MS), and atherosclerosis. We have determined the relationship between the SUA level, MS, and arterial stiffness in Korean. SUBJECTS AND METHODS: Cross-sectional data from 1,276 adults who underwent routine laboratory tests and pulse wave velocity (PWV) measurements during a health check-up were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, diabetes, renal disease, or systemic disease, or were under treatment which would affect SUA levels, or taking medications for hypertension or dyslipidemia. RESULTS: After adjustment for age, smoking status, total cholesterol (TC), and creatinine, the odds ratios (ORs, 95% confidence interval) of gender-specific quartiles of SUA for MS were 1.0, 1.28 (0.66-2.47), 1.46 (0.76-2.82), and 2.21 (1.15-4.26) in females, and 1.0, 1.33 (0.82-2.17), 1.60 (0.96-2.66), and 2.03 (1.21-3.40) in males. However, after adjustment for waist circumference, there were no significant differences in the ORs among the SUA quartile groups in females and males (both, p=NS). The Pearson's correlation coefficients for the relationship between SUA levels and heart-femoral (hf) PWVs or brachial-ankle (ba) PWVs were not significant in females and males (r=0.054 and r=0.015, respectively, in females; r=-0.036 and r=-0.015, respectively, in males; all, p=NS). CONCLUSION: An elevated SUA level is associated with abdominal obesity among the MS components, but the SUA level is not associated with PWV in females or males.
