Analysis of Pulmonary Function Test in Korean Patients With Duchenne Muscular Dystrophy: Comparison of Foreign and Korean Reference Data.
10.5535/arm.2016.40.5.851
- Author:
Tae Sik BANG
1
;
Woo Hyuk CHOI
;
Sang Hun KIM
;
Je Sang LEE
;
Soo Yeon KIM
;
Myung Jun SHIN
;
Yong Beom SHIN
Author Information
1. Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
- Publication Type:Original Article
- Keywords:
Duchenne muscular dystrophy;
Respiratory function test;
Reference values
- MeSH:
Adolescent;
Child;
Cough;
Forced Expiratory Volume;
Humans;
Muscular Dystrophy, Duchenne*;
Reference Values;
Respiratory Function Tests*;
Respiratory Therapy;
Vital Capacity
- From:Annals of Rehabilitation Medicine
2016;40(5):851-861
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To determine the abnormal pulmonary function value in Korean Duchenne muscular dystrophy (DMD) patients, we performed a comparative analysis of the patients' pulmonary function value expressed as % of the overseas reference data and Korean healthy children and adolescent reference data. METHODS: We performed pulmonary function test (PFT) in a total of 27 DMD patients. We compared the patients' FVC% and FEV1% of the overseas reference data with those of the Korean children and adolescent reference data. Also, we compared the patients' MIP% and MEP% of the prediction equation data with those of the Korean children and adolescent reference data. RESULTS: Age of the subjects ranged from 8 to 16 years (12.03±2.27 years). The mean maximal expiratory pressure (MEP), maximal inspiratory pressure (MIP), vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and peak cough flow (PCF) were 36.93±9.5 cmH₂O, 45.79±17.46 cmH₂O, 1.4±0.43 L, 1.45±0.45 L, 1.40±0.41 L, and 206.25±61.21 L/min, respectively. The MIP%, MEP%, and FVC% of the Korean children and adolescent reference data showed statistically significant higher values than those of the prediction equation data. CONCLUSION: We observed a clear numeric difference between Korean DMD patients' pulmonary function value expressed as % of the overseas data and inland data. To perform a precise assessment of respiratory function and to determine appropriate respiratory therapy, pulmonary function values of Korean DMD patients should be interpreted taking into account the inland normal pulmonary function test data.
