A Case of Chronic Tubulointerstitial Nephritis in Methylmalonic Acidemia.
- Author:
Jin Seok LEE
1
;
Hyun Hoe KOO
;
Tae Sun HA
Author Information
1. Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Korea. tsha@med.chungbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Methylmalonic acidemia;
Tubulointerstitial nephritis;
Renal biopsy
- MeSH:
Adolescent;
Biopsy;
Child;
Diet, Protein-Restricted;
Diethylpropion;
Female;
Follow-Up Studies;
Humans;
Metabolism;
Methylmalonic Acid;
Nephritis, Interstitial*
- From:Korean Journal of Nephrology
2003;22(6):749-752
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Methylmalonic acidemia (MMA) is a heterogeneous inborn error of propionate metabolism and its management frequently includes a low-protein diet to minimize precursors of methylmalonic acid and reduce its concentration in body tissues. In the long- term follow-up, renal dysfunction in these patients has been increasingly recognized. Tubulointerstitial nephritis is the most frequent renal complications and has been reported in the small number of renal biopsy specimens from young children previously by others. We report a case of a 18-year-old girl with MMA and renal dysfunction in whom renal biopsy demonstrated chronic tubulointerstitial nephritis.
