A Case of Nicolau Syndrome Due to Diclofenac Sodium.
- Author:
So Jin KIM
1
;
Jung Dae KANG
;
Nyung Hoon YOON
;
Seok Don PARK
Author Information
1. Department of Dermatology, Wonkwang University School of Medicine, Iksan, Korea. sdpark@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Nicolau syndrome;
Diclofenac sodium
- MeSH:
Buttocks;
Dermis;
Diclofenac*;
Epidermis;
Humans;
Middle Aged;
Necrosis;
Skin
- From:Korean Journal of Dermatology
2004;42(3):370-372
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Nicolau syndrome is defined as local cutaneous and sometimes muscular necrosis observed at the injection site of intramuscular preparations. It is characterized by severe pain immediately after the injection and variable degrees of skin necrosis. The only treatment is conservative. A 46-year-old man presented with painful skin necrosis on his buttock after the injection of diclofenac sodium. Histopathologic examination showed necrosis of the epidermis and upper 2/3 of the dermis. The lesion was treated conservatively with topical antibiotic ointment. We report a rare case of Nicolau syndrome due to diclofenac sodium.
