Clinical Analysis of PTEN, p53 and Her-2/neu Expressions in Thyroid Cancers.
- Author:
Jeong Soo KIM
1
;
Ja Seong BAE
;
Kee Hwan KIM
;
Chang Hyeok AHN
;
Se Jeong OH
;
Hae Myung JEON
;
Keun Woo LIM
;
Chung Soo CHUN
Author Information
1. Department of Surgery, Uijongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea. drbreast@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Thyroid neoplasm;
PTEN gene;
p53 gene;
Her-2/neu gene;
Immunohistochemical staining
- MeSH:
Antibodies, Monoclonal;
Biological Factors;
Carcinogenesis;
Dual-Specificity Phosphatases;
Genes, p53;
Genes, Tumor Suppressor;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
PTEN Phosphohydrolase;
Thyroid Gland*;
Thyroid Neoplasms
- From:Cancer Research and Treatment
2001;33(5):433-437
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The dual-specificity phosphatase PTEN/ MMAC1/TEP1 has recently been identified as the tumor suppressor gene most frequently mutated and/or deleted in human tumors. However, PTEN mutations have rarely been detected in sporadic thyroid cancers. Therefore, this study investigated the PTEN expression of thyroid cancer and the relationship between PTEN, clinical status and other biologic factors such as HER-2/neu and p53. MATERIALS AND METHODS: The study samples consisted of 62 thyroid cancer specimens and 24 benign thyroid tumor specimens from patients who were operated on the Department of Surgery, Uijongbu St. Mary's hospital during the 5 years from January 1995 until January 2000. All tumors were studied by immunohistochemical staining using monoclonal antibodies against PTEN, HER-2/neu and p53. The results were analyzed statistically. RESULTS: PTEN protein was found to be under-expressed more frequently in thyroid cancers (29%) than in benign thyroid tumors (4.2%). The reduction in PTEN expression in thyroid cancers was not significantly related with the recorded clinical factors such as size, age, lymph node metastasis and p53, except for HER-2 which was found to be significantly related (p=0.001). HER-2 over- expression was noted in thyroid cancer (83.8%) more frequently than in benign tumors (16.7%). CONCLUSION: This study has demonstrated that the under-expression of PTEN protein and the over-expression of HER-2 protein may play a role in the carcinogenesis and development of thyroid cancer.
