Outcome of Microsurgical Multiple Testicular Sperm Extraction for Patients with Y Chromosome Microdeletion.
- Author:
Won Tae KIM
1
;
Ju Tae SEO
Author Information
1. Department of Urology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. jtand.seo@ samsung.com
- Publication Type:Original Article
- Keywords:
Y chromosome;
Infertility
- MeSH:
Azoospermia;
Humans;
Incidence;
Infertility;
Infertility, Male;
Male;
Sperm Retrieval;
Spermatozoa*;
Y Chromosome*
- From:Korean Journal of Urology
2005;46(8):819-822
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Purpose: Y chromosome microdeletions have been intimately associated with idiopathic male infertility, and the incidence of microdeletions has been reported to 15-20% in men with nonobstructive azoospermia (NOA). We analyzed azoospermic factor (AZF) deletions in NOA patients, and then compared the surgical outcomes after microsurgical multiple testicular sperm extraction (TESE), between patients with and without AZF deletions. Materials and Methods: 90 patients with NOA, who were investigated for microdeletion of Y chromosome, underwent microsurgical multiple TESE. The age, testicular size, endocrinological profile and outcome of sperm retrieval were compared between patients with and without AZF deletions. Results: Y microdeletions were found in 6.7% (6/90). The sperm retrieval rates, without and with microdeletions were 23.8 (20/84) and 50% (3/6), respectively. There were no significant differences in the age, testicular size, endocrinological profile and sperm retrieval rates between the patients with microdeletion and without. Conclusions: Y microdeletions do not affect the sperm retrieval rates of NOA patients.
