Rifampin Induced Rapidly Progressive Glomerulonephritis.
- Author:
Chun Soo LIM
1
;
Yoon Chul JUNG
;
Sang Goo LEE
;
Cu Rie AHN
;
Jin Suk HAN
;
Sung Gwon KIM
;
Jung Sang LEE
;
Hyun Soon LEE
Author Information
1. Department of Internal Medicine, College of Medicine Seoul National University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Rifampin;
Rapidly Progressive Glomerulonephritis;
Henoch-Sch nlein Purpura
- MeSH:
Acute Kidney Injury;
Aged;
Anorexia;
Azotemia;
Biopsy;
Edema;
Glomerulonephritis*;
Glomerulonephritis, IGA;
Humans;
Kidney;
Leg;
Lower Extremity;
Male;
Nausea;
Nephritis, Interstitial;
Prednisolone;
Purpura;
Rifampin*;
Skin;
Tuberculosis, Pulmonary;
Vasculitis
- From:Korean Journal of Nephrology
1998;17(3):503-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Most cases of acute renal failure induced by rifampin are due to acute tubulointerstitial nephritis and usually resolve spontaneously after discontinuation of rifampin. But there were a few reports that rifampin could cause crescentic glomerulonephritis. We present a 67 year-old male patient who has suffered from pulmonary tuberculosis and taken antituberculosis drugs including rifampin. The medication was interrupted two times because of anorexia and nausea. Azotemia, lower extremity edema and palpable purpura on both legs developed after administering antituberculosis drugs for two months. We performed the skin and kidney biopsy. The skin biopsy showed necrotizing vasculitis and kidney biopsy showed crescentic IgA nephropathy. He was tentatively diagnosed as rifampin induced rapidly progressive glomerulonephritis and underlying Henoch-Sch nlein purpura. The antituberculosis regimen was switched excluding rifampin and prednisolone was administered orally. His renal function was improved slowly over 4 months.
