A Case of Rhabdomyolysis with Acute Renal Failure in the Course of Interferon Therapy for Chronic Active Hepatitis B.
- Author:
Sang Soo LEE
1
;
Dong Joon PARK
;
Il Seok CHEON
;
Jeong Ook EIM
;
Woon Tae JUNG
;
Jong Duk LEE
;
Joong Hyun CHO
;
Se Ho CHANG
;
Soon Il CHUNG
Author Information
1. Department of Internal Medicine, College of Medicine, Gyeongsang National University, Chinju, Korea.
- Publication Type:Case Report
- Keywords:
Chronic hepatitis B;
Interferon-alfa;
Rhabdomyolysis;
Acute renal failure
- MeSH:
Acute Kidney Injury*;
Alopecia;
Arthralgia;
Autoimmune Diseases;
Drug Therapy;
Fever;
Hepatitis B virus;
Hepatitis B, Chronic;
Hepatitis, Chronic*;
Humans;
Interferons*;
Leukopenia;
Melanoma;
Myalgia;
Rhabdomyolysis*;
Thrombocytopenia
- From:Korean Journal of Nephrology
1998;17(3):510-515
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Interferon has been tried as a drug of choice in patients with chronic active hepatitis by hepatitis B virus infection since Greenberg has reported the effectiveness of interferon in 1976. The effects of interferon therapy have been reported variably and various complications such as fever, myalgia, arthralgia, flu-like symptoms, temporary leukopenia and thrombocytopenia, alopecia, cardiovascular symptoms and autoimmune diseases have been reported. But rhabdomyolysis has been rarely reported in the interferon therapy of chronic hepatitis B. There were some cases of rhabdomyolysis with acute renal failure in the interferon therapy which was designed for chemotherapy of malignant melanoma and for chronic active hepatitis C virus infection. We reported a case of rhabdomyolysis with acute renal failure developed during the interferon therapy in a patient with chronic active hepatitis B.
