The Prognostic Significance of Silver-Binding Nucleolar Organizer Regions, Proliferating Cell Nuclear Antigen and Flow Cytometric DNA Analysis in Superficial Bladder Tumors.
- Author:
Jun Seok PARK
1
;
Moon Kee CHUNG
Author Information
1. Department of Urology, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Superficial transitional cell carcinoma;
AgNORs;
PCNA;
Flowcytometry
- MeSH:
Aneuploidy;
DNA*;
Drug Therapy;
Incidence;
Logistic Models;
Mycobacterium bovis;
Nucleolus Organizer Region*;
Proliferating Cell Nuclear Antigen*;
Recurrence;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urology
1995;36(4):359-367
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The proliferating activity of the cancer cells was estimated in 67 superficial bladder tumors (26 pTa and 41 pT1) by the silver-binding nucleolar organizer regions(AgNORs), proliferating cell nuclear antigen(PCNA) and flow cytometric DNA analysis. the clinical variances, AgNORs count, PCNA positivity and the incidence of aneuploidy showed no correlation with recurrence statistically. But cytology, grade and PCNA positivity had statistical significance for progression (p<0.0.05). Especially cytology and PCNA positivity showed independent predictive values in multiple logistic regression analysis. We analyzed the values with above mentioned method including intravesical chemotherapy. None of above showed correlation with recurrence statistically. Cytology, grade, BCG therapy and PCNA positivity had statistical significance for progression( p <0.05). But none of those showed statistical significance in multiple logistic regression analysis. In summary, AgNORs count, PCNA positivity and the incidence of aneup1oidy may not have the value of prognostic factor to predict recurrence and/or progression if include intravesical chemotherapy.
