Clinical Predictors of Disease Progression in New-Onset Urticaria.
- Author:
Bo In LEE
1
;
Jee Hyun LEE
;
Young Min PARK
;
Jun Young LEE
Author Information
1. Department of Dermatology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea. jylee@ catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Chronic spontaneous urticaria;
Course;
Prognosis;
Urticaria
- MeSH:
Acute Disease;
Angioedema;
Chronic Disease;
Disease Progression*;
Histamine Antagonists;
Humans;
Medical Records;
Prognosis;
Retrospective Studies;
Urticaria*
- From:Korean Journal of Dermatology
2015;53(2):119-126
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Chronic spontaneous urticaria (CSU) is considered a different disease entity from acute urticaria in relation to its pathogenesis, despite both disease types having similar clinical manifestations that include wheals, flares, and angioedema. OBJECTIVE: We sought to identify the clinical factors that might predict the disease course of new-onset urticaria, determine whether the disease will be limited to an acute course or if it will progress to a chronic course, and to estimate the chronic progression rate in relation to the presence of each clinical factor and laboratory abnormality. METHODS: We retrospectively reviewed the medical records of 348 patients with new-onset urticaria. Of these, 141 patients had progressed to chronic disease and 207 patients showed a limited to acute course with disease durations of less than 6 weeks. We compared the progressed to chronic and limited to acute disease groups in relation to differences in their clinical presentations and severities, and the laboratory data. RESULTS: The overall chronic progression rate of new-onset urticaria was 40.5%. The chronic progression rate was highest in patients aged 30~39 years (52.3%), in patients prescribed antihistamines (52.9%), and when the cause of urticaria was unknown (51.8%). The laboratory test results did not differ significantly between the study groups. CONCLUSION: Patients with new-onset urticaria are likely to have chronic courses when they are aged 30~39 years, when they have mild clinical symptoms initially, and when the cause of urticaria is difficult to identify.
