Differential Regulation of Atrial Natriuretic Peptide in Clipped and Contralateral Kidneys in Two-Kidney, One Clip Hypertension.
- Author:
Soo Wan KIM
1
;
Jong Un LEE
;
Yoon Wha OH
;
Ying Shun LI
;
Nam Ho KIM
;
Ki Chul CHOI
Author Information
1. Department of Physiology, Chonnam National University Medical School, Gwangju, Korea. julee@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
Atrial natriurertic peptide;
Two-kidney;
One clip hypertension
- MeSH:
Animals;
Atrial Natriuretic Factor;
Hypertension*;
Kidney*;
Rats;
Receptors, Peptide;
RNA, Messenger
- From:Korean Journal of Nephrology
2002;21(5):728-733
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The present study was aimed to determine the pathophysiological implications of local atrial natriuretic peptide (ANP) system in the kidney in two- kidney, one clip (2K1C) hypertension. METHODS: Rats were made 2K1C hypertensive, and their mRNA expressions of ANP and natriuretic peptide receptors (NPR) were determined in the clipped and contralateral kidneys by reverse transcription-polymerase chain reaction. RESULTS: The expression of ANP was decreased in the clipped kidney and increased in the contralateral kidney. Similarly, the expression of both NPR-A and NPR-C was decreased in the clipped kidney and increased in the contralateral kidney. CONCLUSION: These findings indicate a differentially-altered ANP system in the clipped and the contralateral kidneys in 2K1C hypertension.
