Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity.
- Author:
Akila DE SILVA
1
;
Stephen R BLOOM
Author Information
1. Department of Diabetes, Endocrinology and Metabolism, Hammersmith Campus, Imperial College London, London, UK. s.bloom@imperial.ac.uk
- Publication Type:Review
- Keywords:
Gut hormones;
Appetite;
Peptide tyrosine tyrosine;
Glucagon-like peptide 1;
Obesity
- MeSH:
Animals;
Appetite;
Eating;
Gastric Bypass;
Glucagon-Like Peptide 1;
Humans;
Obesity;
Peptide Hormones;
Tyrosine
- From:Gut and Liver
2012;6(1):10-20
- CountryRepublic of Korea
- Language:English
-
Abstract:
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.
