Efficacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naive Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study.
- Author:
Mesut SEZIKLI
1
;
Zuleyha Akkan CETINKAYA
;
Fatih GUZELBULUT
;
Atakan YESIL
;
Mustafa Erhan ALTONOZ
;
Nuriye ULU
;
Ayse Oya OVUNC KURDAS
Author Information
1. Department of Gastroenterology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey. drsezikli@hotmail.com
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Tetracycline;
Rescue therapy
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
Amoxicillin;
Clarithromycin;
Helicobacter;
Helicobacter pylori;
Humans;
Pilot Projects;
Proton Pumps;
Tetracycline
- From:Gut and Liver
2012;6(1):41-44
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to evaluate the eradication rate of a triple therapy regimen that included a proton pump inhibitor, amoxicillin, and tetracycline instead of clarithromycin in treatment-Naive patients and in patients who did not respond to standard triple therapy. METHODS: This study included 110 patients infected with Helicobacter pylori. Patients in groups A and B were treatment-Naive, and those in group C were not responsive to previous standard triple therapy. Patients in group A (n=40) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and clarithromycin 500 mg b.i.d. for 14 days. Patients in groups B (n=40) and C (n=30) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and tetracycline 500 mg q.i.d. for 14 days. RESULTS: In group A, eradication was achieved in 18 (45%) of the 40 patients included in the intention-to-treat (ITT) analysis and in 18 (47.4%) of the 38 patients included in the per-protocol (PP) analysis. In group B, eradication was achieved in 15 (37.5%) of the 40 patients included in the ITT analysis and in 15 (39.3%) of the 38 patients included in the PP analysis. In group C, eradication was achieved in 14 (46.6%) of the 30 patients included in the ITT analysis and in 14 (43.8%) of the 29 patients included in the PP analysis. There was no statistically significant difference among the 3 groups with regard to eradication rates (p>0.05). CONCLUSIONS: Despite the low rate of resistance to tetracycline, the combination of lansoprazole, amoxicillin, and tetracycline instead of clarithromycin is not a good option for the eradication of H. pylori.
