Clinical and Molecular Epidemiology of Community-Onset Bacteremia Caused by Extended-Spectrum beta-Lactamase-Producing Escherichia coli over a 6-Year Period.
10.3346/jkms.2013.28.7.998
- Author:
Cheol In KANG
1
;
Min Kyeong CHA
;
So Hyun KIM
;
Kwan Soo KO
;
Yu Mi WI
;
Doo Ryeon CHUNG
;
Kyong Ran PECK
;
Nam Yong LEE
;
Jae Hoon SONG
Author Information
1. Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. collacin@hotmail.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Escherichia coli;
Community-Acquired Infections;
Cephalosporin Resistance;
Bacteremia;
Epidemiology
- MeSH:
Aging;
Bacteremia/drug therapy/*epidemiology;
Biliary Tract Diseases/epidemiology/microbiology;
Cephalosporin Resistance/genetics;
Cephalosporins/therapeutic use;
Community-Acquired Infections/*epidemiology/microbiology;
Escherichia coli/isolation & purification/metabolism;
Escherichia coli Infections/drug therapy/*epidemiology;
Female;
Humans;
Male;
Microbial Sensitivity Tests;
Molecular Epidemiology;
Multilocus Sequence Typing;
Prevalence;
Retrospective Studies;
Urinary Tract Infections/epidemiology/microbiology;
beta-Lactamases/*metabolism
- From:Journal of Korean Medical Science
2013;28(7):998-1004
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) has emerged as a significant community-acquired pathogen, there is little epidemiological information regarding community-onset bacteremia due to ESBL-EC. A retrospective observational study from 2006 through 2011 was performed to evaluate the epidemiology of community-onset bacteremia caused by ESBL-EC. In a six-year period, the proportion of ESBL-EC responsible for causing community-onset bacteremia had increased significantly, from 3.6% in 2006 to 14.3%, in 2011. Of the 97 clinically evaluable cases with ESBL-EC bacteremia, 32 (33.0%) were further classified as healthcare-associated infections. The most common site of infection was urinary tract infection (n=35, 36.1%), followed by biliary tract infections (n=29, 29.9%). Of the 103 ESBL-EC isolates, 43 (41.7%) produced CTX-M-14 and 36 (35.0%) produced CTX-M-15. In the multilocus sequence typing (MLST) analysis of 76 isolates with CTX-M-14 or -15 type ESBLs, the most prevalent sequence type (ST) was ST131 (n=15, 19.7%), followed by ST405 (n=12, 15.8%) and ST648 (n=8, 10.5%). No significant differences in clinical features were found in the ST131 group versus the other group. These findings suggest that epidemic ESBL-EC clones such as CTX-M-14 or -15 type ESBLs and ST131 have disseminated in community-onset infections, even in bloodstream infections, which are the most serious type of infection.
