Pseudo-Kaposi Sarcoma:Differential Diagnosis from Kaposi Sarcoma.
10.5021/ad.2000.12.2.83
- Author:
Kyoung Ae JANG
;
Yeon Soon LIM
;
Jee Ho CHOI
;
Kyung Jeh SUNG
;
Kee Chan MOON
;
Jai Kyoung KOH
- Publication Type:Original Article
- Keywords:
Pseudo-Kaposi sarcoma;
Kaposi sarcoma;
Cutaneous lymphocyte antigen;
Polymerase chain reaction;
Human herpesvirus 8
- MeSH:
Biopsy;
Capillaries;
Chungcheongnam-do;
Dermis;
Diagnosis*;
Diagnosis, Differential;
Endothelial Cells;
Epidermis;
Erythrocytes;
Factor VIII;
Female;
Fibrosis;
Follow-Up Studies;
Herpesvirus 8, Human;
Humans;
Lymphocytes;
Male;
Mali;
Medical Records;
Polymerase Chain Reaction;
Sarcoma;
Sarcoma, Kaposi*;
Vascular Malformations;
Vimentin
- From:Annals of Dermatology
2000;12(2):83-89
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Pseudo-Kaposi sarcoma mimicks Kaposi sarcoma, both clinically and histopathologically. These conditions are due to congenital (Stewart-Bluefarb syndrome) or acquired (Mali) vascular malformations. OBJECTIVES: The purposes of this study were aimed at evaluating the clinical and histopathological characteristics of pseudo-Kaposi sarcoma and finding differential diagnostic tools from Kaposi sarcoma. METHODS: Clinical information of 7 patients with pseudo-Kaposi sarcoma diagnosed in Asan Medical Center from 1989 to 1999 was obtained from the medical records and clinical follow-ups. We re-evaluated 10 biopsy specimens obtained from them and immunohistochemical studies for cutaneous lymphocyte antigen (CLA), CD34, vimentin, and factor VIII were performed with the standard streptavidin-biotin method using paraffin-embedded tissue specimens of 7 pseudo-Kaposi sarcomas and 3 Kaposi sarcomas. In addition, we examined whether human herpesvirus 8 (HHV8) was detected in 3 patients by polymerase chain reaction (PCR). RESULTS: Six male and one female patients were included. Mean age was 36.3 years. Three patients were classified into Mali type and the other four patients were into Stewart-Bludfarb type. Histopathological examinations revealed capillary proliferation in the upper dermis, perivascular infiltrate of inflammatory cells, extravasated red blood cells, and fibrosis of dermis. Anti-factor VIII and CD34 stained endothelial cells only. CLA was expressed in lymphocytic infiltrate in the epidermis and dermis of pseudo-Kaposi sarcoma, whereas it was negative in Kaposi sarcoma. PCR for HHV 8 showed negative results. CONCLUSIONS: Pseudo-Kaposi sarcoma is an uncommon entity with characteristic clinical and histopathological features. Differential diagnosis between Pseudo-Kaopsi sarcoma and Kaposi sarcoma is important. We suggest that detection of HHV 8 by PCR and imunohistochemical study for CLA may be effective tools in the differential diagnosis between them.
