Preliminary Report on Efficacy of Speculoscopy for Increasing the Sensitivity of Cervical Cancer Screening Test.
- Author:
Jong Pil MOON
1
;
Jeong Won CHOI
;
Ill Woon JI
;
Eun Hwan JEONG
;
Hak Soon KIM
Author Information
1. Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Cervical cancer;
Screening;
Pap smear;
Speculoscopy
- MeSH:
Biopsy;
Female;
Humans;
Mass Screening*;
Pathology;
Sensitivity and Specificity;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
2003;46(12):2360-2365
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Since the accuracy of Pap smear for cervical neoplasm has been questioned, a number of adjunctive tests have been developed. The purpose of this study was to evaluate the accuracy of speculoscopy, a magnified chemiluminescent examination, as compared with that of the Pap smear in the screening of cervical neoplasm. METHODS: A total of 41 women were included in the study. We conducted Pap smear, speculoscopy, and punch biopsy to all subjects. Targeted biopsies were obtained from any suspicious lesions that were found with positive speculoscopy. Women with negative speculoscopy underwent random biopsies. The data were analysed using McNemar's test. RESULTS: Thirty-one out of 41 biopsy specimen were found to have cervical lesion that were worse than CIN I, including 8 cases of invasive cancer. The sensitivity and specificity of Pap smear were 74.2% and 70.0%, respectively. Those of speculoscopy were 93.5% and 60.0%, respectively. When these two tests were combined, the sensitivity was raised to 96.8%, but the specificity declined to 50.0%. Among 9 cases of ASCUS on Pap smear, 6 cases were found to have cervical pathology worse than CIN II, and these were positive on speculoscopy. CONCLUSION: Speculoscopy combined with a Pap smear can increase the detection of cervical lesions compared with the Pap smear alone. In the cases of ASCUS on Pap smear, speculoscopy may be more useful to detect significant pathology.
