Corporeal blood gas changes according to duration of drug-induced prolonged erection.
10.3346/jkms.1993.8.3.202
- Author:
Sae Chul KIM
1
;
Kyeng Keun SEO
;
Chung Hwan OH
Author Information
1. Department of Urology, College of Medicine, Chung-Ang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Corporeal blood gas;
Drug-inducedprolonged erection
- MeSH:
Adult;
Carbon Dioxide/*blood;
Erectile Dysfunction/*blood/drug therapy;
Femoral Artery;
Humans;
Hydrogen-Ion Concentration;
Male;
Middle Aged;
Oxygen/*blood;
Papaverine/administration & dosage/therapeutic use;
Penile Erection/*drug effects;
Phentolamine/administration & dosage/therapeutic use;
Time Factors
- From:Journal of Korean Medical Science
1993;8(3):202-206
- CountryRepublic of Korea
- Language:English
-
Abstract:
The corporeal blood gas changes in accordance with the duration of the prolonged erection which developed after intracorporeal pharmacotherapy with papaverine and phentolamine were investigated in 62 impotence patients. The picture of the corporeal blood taken from 15 psychogenic impotence patients (a control group) at 10 minutes after intracavernous injection when they showed full erections was arterial but there was pCO2 rise and pH drop compared to femoral artery blood taken simultaneously. As the erection lasted longer, significant gas changes of the cavernous blood began to appear (p<0.0001): increase in pCO2 and decrease in pO2 from 4 hours, decrease in pH from 5 hours, decrease in O2 saturation from 6 hours. Erections lasting for more than 16 hours showed significantly worse hypoxia (p<0.05). Therefore, to prevent hypoxia and metabolic acidosis, drug-induced prolonged erection would be better decompressed before it lasts for more than 4 hours.
