Peripheral neuropathy as a hypereosinophilic syndrome and anti-GM1 antibodies.
10.3346/jkms.1993.8.3.225
- Author:
Geun Ho LEE
1
;
Kwang Woo LEE
;
Je Geun CHI
Author Information
1. Department of Neurology, College of Medicine, Seoul National University, Korea.
- Publication Type:Case Reports
- Keywords:
Peripheral neuropathy;
hypereosinophilic syndrome;
anti-GM;
antibody
- MeSH:
Acute Disease;
Adult;
Antibodies/*blood;
G(M1) Ganglioside/*immunology;
Humans;
Hypereosinophilic Syndrome/*complications/immunology;
Male;
Peripheral Nervous System Diseases/*etiology
- From:Journal of Korean Medical Science
1993;8(3):225-229
- CountryRepublic of Korea
- Language:English
-
Abstract:
The acute peripheral neuropathy as one of hypereosinophilic syndrome is known to be a rare disorder. The authors experienced a dramatic case with acute peripheral neuropathy, hypereosinophilia in peripheral blood, and the positive anti-GM1 antibodies. The serum protein electrophoresis showed a diffusely increased gamma-globulin region and the polyclonal gammopathy was found by the immunoelectropheresis. There was no evidence of inflammatory myopathy in vastus lateralis muscle. The sural nerve biopsy was compatible with vascular neuropathy, as there were a few myelin digestion chambers, mild perineuronal fibrosis, and perivascular lymphoplasmocytic infiltration with focal organizing thrombosis. The clinical response to prednisone therapy was excellent.
