A Case of Familiar Benign Chronic Pemphigus.
- Author:
Nack In KIM
;
Choon Bong LEE
;
Moo HYUNG
;
Choong Rim HAW
- Publication Type:Case Report
- Keywords:
Familial benign chronic pemphigus;
Perianal;
Electron microscopic study
- MeSH:
Adult;
Biopsy;
Desmosomes;
Extracellular Space;
Humans;
Intermediate Filaments;
Microvilli;
Pemphigus, Benign Familial*;
Physical Examination
- From:Korean Journal of Dermatology
1987;25(5):716-721
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 25-year-old man with familial benign chronic pemphigus presented with a one-year history of a localized pruritic recurrent eruption on his perianal area, Physical examination showed moist, macerated, fissured and scaly patches on erythematous base, A biopsy specimen showed extensive intraepidermal separation containing acantholytic cells. Electron microscopic observation showed widened intercellular space, detachment of the tonofilaments from the desmosomes, and subsequent concentration of the tono filaments around the nucleus. Microvilli were elorigated, thinned and branehed. 1)esmosomes were reduced in number. This case is unique in its clinical location, showing no family tendency.