Changes of Calretinin-Immunoreactivities in the Rat Superior Collicuclus after Eye Enucleation.
10.11637/kjpa.2005.18.3.179
- Author:
Sang Pil YOON
1
;
Han Yong KIM
;
Young Jin JUN
;
In Youb CHANG
Author Information
1. Department of Anatomy, 1Plastic Surgery, College of Medicine, Seonam University, Korea.
- Publication Type:Original Article
- Keywords:
Calretinin;
Superior colliculus;
Monocular enucleation;
Rat
- MeSH:
Animals;
Calbindin 2;
Calcium-Binding Proteins;
Central Nervous System;
Cholera Toxin;
Eye Enucleation*;
Neurons;
Rats*;
Retinaldehyde;
Superior Colliculi
- From:Korean Journal of Physical Anthropology
2005;18(3):179-186
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Calcium-binding proteins play an important role in the protection, differentiation, and reorganization of the central nervous system. The effects of neonatal retinal deafferentiation on calretinin, and tracing of retinotectal pathway were examined immunohistochemically in the superficial layer of the rat superior colliculus. Tracing with cholera toxin was revealed on the superior colliculus contralateral to the ocular injection. On the contralateral side of superior colliculus, the calretinin-immunoreactive (IR) cells were dramatically increased, calretinin-IR fibers were markedly decreased in the superficial layer. These results show that retinal deafferentation results in an increase of calretinin-immunoreactive cells within the superficial layers of the superior colliculus, which suggest reorganization of neurons in superior colliculus.
