Impact of graft composition on the systemic inflammatory response after an elective repair of an abdominal aortic aneurysm.
10.4174/astr.2015.88.1.21
- Author:
Jong Kwan BAEK
1
;
Hyunwook KWON
;
Gi Young KO
;
Min Joo KIM
;
Youngjin HAN
;
Young Soo CHUNG
;
Hojong PARK
;
Tae Won KWON
;
Yong Pil CHO
Author Information
1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ypcho@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Graft;
Composition;
Inflammatory response;
Aorta;
Aneurysm
- MeSH:
Aneurysm;
Aorta;
Aortic Aneurysm, Abdominal*;
Hospitalization;
Humans;
Incidence;
Leukocyte Count;
Multivariate Analysis;
Polyesters;
Retrospective Studies;
Risk Factors;
Systemic Inflammatory Response Syndrome;
Transplants*
- From:Annals of Surgical Treatment and Research
2015;88(1):21-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The present study aimed to evaluate the risk factors and the role of graft material in the development of an acute phase systemic inflammatory response, and the clinical outcome in patients who undergo endovascular aneurysm repair (EVAR) or open surgical repair (OSR) of an abdominal aortic aneurysm (AAA). METHODS: We retrospectively evaluated the risk factors and the role of graft material in an increased risk of developing systemic inflammatory response syndrome (SIRS), and the clinical outcome in patients who underwent EVAR or OSR of an AAA. RESULTS: A total of 308 consecutive patients who underwent AAA repair were included; 178 received EVAR and 130 received OSR. There was no significant difference in the incidence of SIRS between EVAR patients and OSR patients. Regardless of treatment modality, SIRS was observed more frequently in patients treated with woven polyester grafts. Postoperative hospitalization was significantly prolonged in patients that experienced SIRS. In multivariate analyses, the initial white blood cell count (P = 0.001) and the use of woven polyester grafts (P = 0.005) were significantly associated with an increased risk of developing SIRS in patients who underwent EVAR. By contrast, the use of woven polyester grafts was the only factor associated with an increased risk of developing SIRS in patients who underwent OSR, although this was not statistically significant (P = 0.052). CONCLUSION: The current study shows that the graft composition plays a primordial role in the development of SIRS, and it leads to prolonged hospitalization in both EVAR and OSR patients.
