Combination Therapy of Topical CCB (Combination of Calcipotriol and Betamethasone Dipropionate) Gel and Narrowband Ultraviolet B (NBUVB) in the Treatment of Vitiligo: An Intraindividual Right-Versus-Left Comparison Study with Topical Betamethasone Dipropi.
- Author:
Seung Min HA
1
;
Ki Hoon SONG
;
Ki Ho KIM
Author Information
1. Department of Dermatology, College of Medicine, Dong-a University, Busan, Korea. khkim@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Betamethasone dipropionate;
Calcipotriol;
Combination therapy;
Repigmentation;
Vitiligo
- MeSH:
Adrenal Cortex Hormones;
Atrophy;
Betamethasone*;
Burns;
Sensation;
Vitiligo*
- From:Korean Journal of Dermatology
2015;53(10):760-765
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In the treatment of vitiligo, topical corticosteroids are known to be effective, but are associated with serious adverse effects. Many studies have shown that topical calcipotriol is a promising therapeutic modality in vitiligo. In some studies, combined calcipotriol and betamethasone dipropionate ointment has been shown to be a more effective and well tolerated treatment for vitiligo. The combination therapy seems to synergistically act as an immunosuppressive and a pigment restorative agent. OBJECTIVE: We investigated the clinical efficacy of CCB (Combination Calcipotriol and Betamethasone dipropionate) gel compared with that of betamethasone dipropionate alone in the repigmentation of vitiligo. METHODS: In an intraindividual right-left comparison study (n=20), a CCB gel was applied once daily to a lesion on one side, and betamethasone dipropionate cream was applied to a lesion on the other side. The degree of repigmentation was assessed according to the Vitiligo Area Scoring Index (VASI) at baseline, 4, 12, 24, and 48 weeks. RESULTS: The CCB gel treated group showed a remarkably improved therapeutic outcome compared to the betamethasone dipropionate monotherapy group: the percentages of VASI relative to the baseline at CCB gel treated sites were 82.73+/-8.17%, 70.45+/-14.05%, 62.73+/-17.52%, and 56.24+/-18.49% at 4, 12, 24, and 48 weeks after treatment, respectively; while those of the other sites receiving betamethasone dipropionate were 89.55+/-7.24%, 84.55+/-10.60%, 77.73+/-14.38%, and 73.48+/-12.93%. Adverse effects such as atrophy and burning sensations were much less after CCB gel treatment than after betamethasone monotherapy. CONCLUSION: CCB gel is more effective and tolerable than betamethasone dipropionate monotherapy in repigmentation therapy for vitiligo.
