A Case of ANCA-associated Pauci-immune Crescentic Glomerulonephritis in Juvenile Rheumatoid Arthritis.
- Author:
You Sik HWANG
1
;
Young Jun RHIE
;
Sun Young AHN
;
Dong Soo KIM
;
Jae Seung LEE
;
Hyun Joo JEONG
Author Information
1. Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea. jsyonse@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Juvenile rheumatoid arthritis;
ANCA;
Crescentic glomerulonephritis
- MeSH:
Adolescent;
Amyloidosis;
Antibodies, Antineutrophil Cytoplasmic;
Arthritis, Juvenile*;
Child;
Complement System Proteins;
Connective Tissue Diseases;
Creatinine;
Glomerulonephritis*;
Hematuria;
Humans;
Immunoglobulins;
Korea;
Male;
Methylprednisolone;
Proteinuria
- From:Journal of the Korean Society of Pediatric Nephrology
2005;9(2):231-236
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Juvenile rheumatoid arthritis(JRA) is the most common major connective tissue disease in children. Renal involvement in JRA is rare. Among the renal lesions that have been reported in JRA, amyloidosis and drug-induced nephropathy are the most common. Crescentic glomerulonephritis in JRA has rarely been reported. We report a case of ANCA-associated pauci-immune crescentic glomerulonephritis in JRA. The patient was a 15-year old boy with a 3-year history of JRA. He presented with gross hematuria, proteinuria, positive p-ANCA and elevation of BUN and creatinine. Pathologic findings revealed focal necrotizing and crescentic glomerulonephritis. There were no significant immunoglobulin or complement deposits. His renal function recovered after intravenous methylprednisolone pulse therapy and oral steroid use. In Korea, this is the first reported case of pauci-immune crescentic glomerulonephritis in JRA.
