A Case of Reversible Posterior Leukoencephalopathy Syndrome during Methylprednisolone Pulse and Cyclophosphamide Therapy in a Child with Nephrotic Syndrome.
- Author:
Joo Hee SEO
1
;
Jung Wook SHIN
;
Ji Hong KIM
;
Choon Sik YOON
Author Information
1. Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea. kkkjhd@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Reversible posterior leukoencephalopathy syndrome;
Nephrotic syndrome;
Steroid pulse therapy;
Cyclophosphamide
- MeSH:
Child*;
Cyclophosphamide*;
Eclampsia;
Edema;
Female;
Headache;
Humans;
Hypertensive Encephalopathy;
Leukoencephalopathies;
Methylprednisolone*;
Nephrotic Syndrome*;
Neurologic Manifestations;
Parietal Lobe;
Posterior Leukoencephalopathy Syndrome*;
Pregnancy;
Seizures;
Vomiting
- From:Journal of the Korean Society of Pediatric Nephrology
2005;9(2):245-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The syndrome of reversible posterior leukoencephalopathy syndrome(RPLS) is characterized clinically by acute neurologic signs such as headache, vomiting, confusion, seizures, and visual abnormalities. Radiologically, abnormalities consistent with reversible white matter edema in the occipital and parietal lobes are characteristic. RPLS has often been associated with various systemic disorders, such as hypertensive encephalopathy, eclampsia, and the use of intravenous or intrathecal immunosuppressive drugs. We report a case of RPLS that occurred after intravenous steroid pulse therapy and treatment with oral cyclophosphamide in a child with nephrotic syndrome, and we emphasize the importance of early recognition of RPLS in the treatment of nephrotic syndrome and appropriate management to prevent permanent neurologic disability.
