Apoptotic Effect of Macrophages against Mycobacterium tuberculosis.
10.4167/jbv.2016.46.4.312
- Author:
Lee Han KIM
1
;
Sung Jae SHIN
Author Information
1. Department of Microbiology, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. sjshin@yuhs.ac
- Publication Type:Review
- Keywords:
Mycobacterium tuberculosis;
Apoptosis;
Bcl-2 family proteins;
Anti-apoptotic proteins;
Pro-apoptotic proteins
- MeSH:
Apoptosis;
Apoptosis Regulatory Proteins;
Cell Death;
Humans;
Inhalation;
Macrophages*;
Macrophages, Alveolar;
Mycobacterium tuberculosis*;
Mycobacterium*;
Tuberculosis
- From:Journal of Bacteriology and Virology
2016;46(4):312-318
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.
