Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus.
10.6065/apem.2014.19.4.191
- Author:
Shin Hee KIM
1
;
In Ah JUNG
;
Yeon Jin JEON
;
Won Kyoung CHO
;
Kyoung Soon CHO
;
So Hyun PARK
;
Min Ho JUNG
;
Byoung Kyu SUH
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. jmhpe@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Dyslipidemia;
Glycemic index;
Prevalence;
Young adult
- MeSH:
Adolescent*;
Body Mass Index;
Cholesterol;
Cross-Sectional Studies;
Diabetes Mellitus;
Diabetes Mellitus, Type 1*;
Dyslipidemias;
Female;
Glycemic Index;
Hemoglobin A, Glycosylated;
Humans;
Linear Models;
Lipoproteins;
Prevalence;
Triglycerides;
Young Adult*
- From:Annals of Pediatric Endocrinology & Metabolism
2014;19(4):191-196
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM). METHODS: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis. RESULTS: Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC> or =200 mg/dL in 8 patients, LDL-C> or =130 mg/dL in 4 patients, TG> or =150 mg/dL in 2 patients, and HDL-C< or =35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R2=0.156) and TG (P=0.005, R2=0.261). CONCLUSION: A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.
