Giant Invasive Sacral Schwannoma Showing Chromosomal Numerical Aberrations -14,+18,+22.

Author: Masahiko KANAMORI ¹ ; Taketoshi YASUDA ; Takeshi HORI ; Kayo SUZUKI
Author Information

1. Department of Human Science, University of Toyama, Toyama, Japan. kanamori@med.u-toyama.ac.jp
Publication Type:Case Report
Keywords: Sacrum; Neurilemmoma; Cytogenetics
MeSH: Buttocks; Chromosomes, Human, Pair 22; Cytogenetics; Female; Humans; Middle Aged; Neurilemmoma; Recurrence; Sacrum; Trisomy
From:Asian Spine Journal 2013;7(3):227-231
CountryRepublic of Korea
Language:English
Abstract: Here, we report on a rare case of a giant invasive sacral schwannoma. The patient was a 58-year-old woman who had a 6-year history of non-specific buttock pain. Histological investigation confirmed the diagnosis of cellular schwannoma. The following numerical aberration was detected using the GTG-banding method for karyotypes: 47,XX,-14,+18,+22. Cytogenetic studies of schwannomas have indicated a complete or partial loss of chromosome 22 as the most common abnormality, but this case is cytogenetically rare because of the recurrence of trisomy 22.