A Case of Phoma glomerata Keratitis Occurred in Recurrent Herpes Simplex Keratitis Cicatrix.
10.3341/jkos.2014.55.8.1229
- Author:
Jong Hwa JUN
1
;
Nam Hee RYOO
;
Sung Dong CHANG
Author Information
1. Department of Ophthalmology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. changsd@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Cicatrix;
Herpes simplex;
Keratitis;
Phoma glomerata;
Recurrent
- MeSH:
Amnion;
Amphotericin B;
Antifungal Agents;
Cicatrix*;
Fluconazole;
Freezing;
Herpes Simplex;
Humans;
Keratitis*;
Keratitis, Herpetic*;
Male;
Middle Aged;
Natamycin;
Ophthalmic Solutions;
Potassium;
Sequence Analysis, DNA
- From:Journal of the Korean Ophthalmological Society
2014;55(8):1229-1232
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of Phoma glomerata keratitis occurring in recurrent herpes simplex keratitis cicatrix. CASE SUMMARY: A 63-year-old male patient was admitted to our hospital with complaints of abrupt visual deterioration and ocular pain in his left eye. He was treated for recurrent herpes simplex keratitis in the same eye 12 years prior. Because central desmatocele was observed as a result of advanced corneal stromal melting, Gram staining, Potassium Hydroxide (KOH) mount, and culture were performed in corneal scrape specimens. On microbiological evaluation, a Phoma species was detected and Phoma glomerata was diagnosed using DNA sequencing method. Two consecutive amniotic membrane transplantations were performed with topical antifungal agents. The lesion was not improved when using topical amphotericin B and natamycin eyedrops, thus fluconazole eyedrops were used additionally. The corneal infection was resolved with central thick opacification. CONCLUSIONS: In the present case, herpetic keratitis was the main underlying causative factor because the patient had no past history of trauma. When diverse appearances of keratitis occur in herpes simplex keratitis patients, clinicians need to consider the concurrence of fungal infection, especially Phoma glomerata, a rare fungal organism.
