ider (9) (q10)t (9;22) (q34;q11.2) as Secondary Karyotypic Aberration of Chronic Myelogeous Leukemia.
- Author:
Gui Jeon CHOI
1
;
Dong Seok JEON
;
Hyo Jin CHUN
;
Jae Ryong KIM
;
Hong Suk SONG
;
Joong Won LEE
Author Information
1. Department of Clinical Pathology, College of Medicine, Keimyung University, Korea.
- Publication Type:Original Article
- Keywords:
ider (9) (q10)t (9;
22) (q34;
q11.2);
Blast crisis;
Chronic myeloid leukemia
- MeSH:
Blast Crisis;
Chromosome Aberrations;
Disease Progression;
Humans;
Leukemia*;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Philadelphia Chromosome;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Precursor Cells, B-Lymphoid
- From:Korean Journal of Clinical Pathology
1999;19(2):266-270
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although occasional patients with chronic myeloid leukemia (CML) have chromosomal changes other than Philadelphia chromosome early in the disease, in typical cases the 9;22 translocation remains the sole abnormality throughout the disease course in chronic phase. When disease progression occurs, however, 75-80% develop additional chromosome aberrations. These secondary changes sometimes precede the more aggressive manifestations hematologically and clinically and thus may serve as valuable prognostic indicators. ider (9) (q10)t (9;22) (q34;q11.2) is very rare and a recurrent chromosomal abnormality associated with acute lymphoblastic leukemias (ALL) and lymphoblastic crisis of CML. And ider (9) (q10)t (9;22) (q34;q11.2) is a lymphoid-specific rearrangement and the patients with this abnormality are of older age on average. They commonly show pre-B cell lineage immunophenotype and L2 morphology. We report a case of ider (9) (q10)t (9;22) (q34;q11.2) as secondary aberration in a patient with lymphoblastic crisis of CML.
