Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis.
10.3349/ymj.2014.55.2.476
- Author:
Dong Yeob SHIN
1
;
Kwang Joon KIM
;
Daham KIM
;
Sena HWANG
;
Eun Jig LEE
Author Information
1. Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ejlee423@yuhs.ac
- Publication Type:Original Article
- Keywords:
Vitamin D deficiency;
anti-thyroid peroxidase antibody;
autoimmune thyroiditis
- MeSH:
Antibodies;
Body Mass Index;
Endocrinology;
Humans;
Methods;
Peroxidase*;
Thyroid Diseases;
Thyroid Gland;
Thyroiditis, Autoimmune*;
Vitamin D Deficiency;
Vitamin D*;
Vitamins*
- From:Yonsei Medical Journal
2014;55(2):476-481
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS AND METHODS: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. RESULTS: The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6+/-5.5 ng/mL vs. 14.5+/-7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group. CONCLUSION: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
