Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus.
10.5051/jpis.2016.46.5.350
- Author:
Jae Shin KIM
1
;
Jae Kook CHA
;
Jung Seok LEE
;
Seong Ho CHOI
;
Kyoo Sung CHO
Author Information
1. Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea. KSCHO@yuhs.ac
- Publication Type:Original Article
- Keywords:
Bone morphogenetic proteins;
Physiologic calcification;
Hydroxyapatite-beta tricalcium phosphate;
Sinus floor augmentation
- MeSH:
Animals;
Bone Morphogenetic Proteins;
Calcification, Physiologic;
Calcium*;
Maxillary Sinus;
Miners*;
Rabbits;
Sinus Floor Augmentation;
Transplants
- From:Journal of Periodontal & Implant Science
2016;46(5):350-359
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of the present study was to evaluate the effectiveness of a minimal concentration of bone morphogenetic protein-2 (BMP-2) in terms of quantitative and qualitative analyses of newly formed bone in a rabbit maxillary sinus model. METHODS: In 7 rabbits, sinus windows were prepared bilaterally. Biphasic calcium phosphate (BCP) loaded with 0.05 mg/mL BMP-2 was grafted into one sinus (the BMP group) and saline-soaked BCP was placed into the other (the control group) in each animal. The animals were allowed an 8-week healing period before being sacrificed. Specimens including the augmented area and surrounding tissues were then removed and evaluated both radiographically and histologically. RESULTS: There was a difference in the mineralization of new bone between the groups. In the BMP group, the greater part of the new bone consisted of mature lamellar bone with an evident trabecular pattern, whereas the control group showed mostly woven bone, consisting only partially of lamellar bone. Histometrically, the area of new bone was significantly greater (4.55±1.35 mm2 vs. 2.99±0.86 mm2) in the BMP group than in the control group (P<0.05); however, the total augmentation volumes were not significantly different between the groups. CONCLUSIONS: Within the limitations of this study, it can be suggested that a minimal concentration of BMP-2 (0.05 mg/mL) had an osteoinductive effect with accelerated mineralization in a rabbit sinus model using a BCP carrier.
