Prevalence of Irritable Bowel Syndrome–like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease.
- Author:
Toshihiko TOMITA
1
;
Yu KATO
;
Mayu TAKIMOTO
;
Takahisa YAMASAKI
;
Takashi KONDO
;
Tomoaki KONO
;
Katsuyuki TOZAWA
;
Yoko YOKOYAMA
;
Hisatomo IKEHARA
;
Yoshio OHDA
;
Tadayuki OSHIMA
;
Hirokazu FUKUI
;
Shigemi TANAKA
;
Masayuki SHIMA
;
Jiro WATARI
;
Hiroto MIWA
Author Information
- Publication Type:Original Article
- Keywords: Anxiety; Inflammatory bowel diseases; Irritable bowel syndrome; Quality of life
- MeSH: Anti-Anxiety Agents; Anxiety; Asian Continental Ancestry Group*; Colitis, Ulcerative; Depression; Gastrointestinal Diseases; Humans; Inflammatory Bowel Diseases*; Irritable Bowel Syndrome; Prevalence*; Quality of Life; Risk Factors
- From:Journal of Neurogastroenterology and Motility 2016;22(4):661-669
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Few studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has 3 objectives: (1) to assess the prevalence of IBS-like symptoms in Japanese patients with inactive IBD using Rome III criteria, (2) to examine the relationship of IBS-like symptoms to health related quality of life (HR-QOL), and (3) to investigate associations for developing IBS-like symptoms in patients with inactive IBD. METHODS: IBS-like symptoms were evaluated using the Rome III questionnaire for functional gastrointestinal disorders. HR-QOL and hospital anxiety and depression scale were evaluated. RESULTS: IBS-like symptoms were found in 17.5% (7/40) of patients with inactive ulcerative colitis, 27.1% (29/107) of patients with inactive Crohn’s disease (CD), and 5.3% (23/438) of healthy control subjects. The QOL level was significantly lower and anxiety score was significantly higher in inactive CD patients with IBS-like symptoms than in those without such symptoms (P = 0.003, P = 0.009). Use of anti-anxiety drugs was associated with the presence of IBS symptoms (P = 0.045). HR-QOL score was lower and anxiety score was higher in patients with inactive ulcerative colitis, but the difference was not statistically significant. CONCLUSIONS: The prevalence of IBS-like symptoms in inactive IBD patients was significantly higher than in healthy controls. Inactive CD patients with IBS-like symptoms has low QOL and anxiety; suggesting that anxiety may be associated with symptom development in such patients.
