A case of the primary ovarian malignant melanoma arising from a cystic teratoma.
- Author:
Yong Sung CHOI
1
;
Chul Won JUNG
;
Jeong KIM
;
Geun Woo PARK
;
Yeon Lim SEO
;
Se Hoon PARK
;
Keunchil PARK
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. leukemia@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Ovarian neoplasm;
Melanoma;
Teratoma
- MeSH:
Abdominal Pain;
Brain;
Cisplatin;
Dacarbazine;
Female;
Follow-Up Studies;
Humans;
Interleukin-2;
Laparotomy;
Melanoma*;
Middle Aged;
Neoplasm Metastasis;
Ovarian Cysts;
Ovarian Neoplasms;
Ovary;
Teratoma*;
Vinblastine
- From:Korean Journal of Medicine
2004;66(6):644-648
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary malignant melanoma arising in a cystic teratoma of ovary is extremely rare. Approximately 25 cases of primary malignant melanoma arising from a cystic teratoma in ovary have been reported in the literature. The malignant transformation of benign cystic teratoma of ovary usually develops unilaterally in postmenopausal women. The common presenting symptoms are abdominal distention, lower abdominal pain and a palpable abdominal mass. We report a case of primary malignant melanoma of ovary in a 45-year-old patient who underwent laparotomy for evaluation of a cystic mass in right ovarian cystic teratoma. Histopathological examination of the cyst showed that it was melanoma with pre-existed teratomatous components. Extraovarian primary site was not found. Nine years after the excision, brain metastases developed which were pathologically confirmed as metastatic melanoma. The patient subsequently developed pulmonary metastases and received immunochemotherapy consisting of cisplatin, dacarbazine, vinblastine, interleukin-2 and interferone-alpha. She is on a regular follow-up and continues to have stable disease for 9 months.
