Clinical and Radiographic Features of Adult-onset Ankylosing Spondylitis in Korean Patients: Comparisons between Males and Females.
10.3346/jkms.2010.25.4.532
- Author:
Young Ok JUNG
1
;
Inje KIM
;
Suho KIM
;
Chang Hee SUH
;
Han Jung PARK
;
Won PARK
;
Seoung Ryul KWON
;
Jae Cheon JEONG
;
Yun Jong LEE
;
Hee Jung RYU
;
Young Bae PARK
;
Jisoo LEE
;
You Hyun LEE
;
Young Il SEO
;
Won Tae CHUNG
;
Seung Jae HONG
;
Yeon Sik HONG
;
Han Joo BAEK
;
Hyo Jin CHOI
;
Hyo Jong KANG
;
Chan Hee LEE
;
Sang Hyon KIM
;
Hyun Ah KIM
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Spondylitis;
Ankylosing
- MeSH:
Adult;
Age of Onset;
*Asian Continental Ancestry Group;
Female;
HLA-B27 Antigen/diagnostic use;
Humans;
Joints/pathology;
Male;
Severity of Illness Index;
Spondylitis, Ankylosing/diagnosis/*pathology/*physiopathology/*radiography
- From:Journal of Korean Medical Science
2010;25(4):532-535
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to investigate clinical and radiographic features and gender differences in Korean patients with adult-onset ankylosing spondylitis. Multicenter cross-sectional studies were conducted in the rheumatology clinics of 13 Korean tertiary referral hospitals. All patients had a confirmed diagnosis of ankylosing spondylitis according to the modified New York criteria. Clinical, laboratory, and radiographic features were evaluated and disease activities were assessed using the Bath ankylosing spondylitis disease activity index. Five hundred and five patients were recruited. The male to female ratio was 6.1:1. Average age at symptom onset was 25.4+/-8.9 yr and average disease duration was 9.6+/-6.8 yr. Males manifested symptoms at a significantly earlier age. HLA-B27 was more frequently positive in males. Hips were more commonly affected in males, and knees in females. When spinal mobility was measured using tragus-to-wall distance and the modified Schober's test, females had significantly better results. Radiographic spinal changes, including bamboo spine and syndesmophytes, were more common in males after adjustment of confounding factors. In conclusion, we observed significant gender differences in radiographic spinal involvement as well as other clinical manifestations among Korea patients with adult-onset ankylosing spondylitis. These findings may influence the timing of the diagnosis and the choice of treatment.
