Influence of Transforming Growth Factor-beta1 Gene Polymorphism at Codon 10 on the Development of Cirrhosis in Chronic Hepatitis B Virus Carriers.
10.3346/jkms.2010.25.4.564
- Author:
Sang Kyun YU
1
;
Oh Sang KWON
;
Hyuk Sang JUNG
;
Kyung Suk BAE
;
Kwang An KWON
;
Yu Kyung KIM
;
Yun Soo KIM
;
Ju Hyun KIM
Author Information
1. Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea. osshsjuj@yahoo.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Hepatitis B Virus;
Liver Cirrhosis;
Polymorphism;
Transforming Growth Factor beta1
- MeSH:
Aged;
Asian Continental Ancestry Group/genetics;
*Carrier State;
*Codon;
Female;
Genetic Predisposition to Disease;
Genotype;
Hepatitis B virus/genetics;
*Hepatitis B, Chronic/genetics/virology;
Humans;
*Liver Cirrhosis/genetics/virology;
Male;
Middle Aged;
Odds Ratio;
*Polymorphism, Genetic;
Risk Factors;
Transforming Growth Factor beta1/*genetics
- From:Journal of Korean Medical Science
2010;25(4):564-569
- CountryRepublic of Korea
- Language:English
-
Abstract:
Transforming growth factor (TGF)-beta1 is a key cytokine producing extracellular matrix. We evaluated the effect of TGF-beta1 gene polymorphism at codon 10 on the development of cirrhosis in patients with chronic hepatitis B. One hundred seventy eight patients with chronic hepatitis (CH, n=57) or liver cirrhosis (LC, n=121), who had HBsAg and were over 50 yr old, were enrolled. The genotypes were determined by single strand conformation polymorphism. There were no significant differences in age and sex ratio between CH and LC groups. HBeAg positivity and detection rate of HBV DNA were higher in LC than in CH groups (P=0.055 and P=0.003, respectively). There were three types of TGF-beta1 gene polymorphism at codon 10: proline homozygous (P/P), proline/leucine heterozygous (P/L), and leucine homozygous (L/L) genotype. In CH group, the proportions of P/P, P/L, and L/L genotype were 32%, 51%, and 17%, respectively. In LC group, the proportions of those genotypes were 20%, 47%, and 33%, respectively. The L/L genotype was presented more frequently in LC than in CH groups (P=0.017). Multivariate logistic regression analysis confirms that detectable HBV DNA (odds ratio [OR]: 3.037, 95% confidence interval [CI]: 1.504-6.133, P=0.002) and L/L genotype (OR: 3.408, 95% CI: 1.279-9.085, P=0.014) are risk factors for cirrhosis.
