Photodynamic Therapy (PDT): PDT Mechanisms.

Author: Ron R ALLISON ¹ ; Keyvan MOGHISSI
Author Information

1. 21st Century Oncology, Greenville, NC, USA.
Publication Type:Review
Keywords: Photochemotherapy; Mechanisms; Photosensitizing agents; Photodynamic reaction
MeSH: Humans; Light; Oxygen; Photochemotherapy; Photosensitizing Agents; Triazenes
From:Clinical Endoscopy 2013;46(1):24-29
CountryRepublic of Korea
Language:English
Abstract: Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how they may be manipulated to improve clinical outcome in cancer patients.