Low-Intensity Shock Wave Therapy and Its Application to Erectile Dysfunction.
10.5534/wjmh.2013.31.3.208
- Author:
Hongen LEI
1
;
Jing LIU
;
Huixi LI
;
Lin WANG
;
Yongde XU
;
Wenjie TIAN
;
Guiting LIN
;
Zhongcheng XIN
Author Information
1. Andrology Center, Department of Urology, Peking University First Hospital, Peking University, Beijing, China. xinzc@bjmu.edu.cn
- Publication Type:Review
- Keywords:
Erectile dysfunction;
ESWL;
Extracorporeal shockwave lithotripsy;
Phosphodiesterase 5 inhibitors
- MeSH:
Animals;
Erectile Dysfunction*;
Hemodynamics;
Lithotripsy;
Male;
Models, Animal;
Penis;
Peripheral Nervous System Diseases;
Phosphodiesterase 5 Inhibitors;
Shock*
- From:The World Journal of Men's Health
2013;31(3):208-214
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although phosphodiesterase type 5 inhibitors (PDE5Is) are a revolution in the treatment of erectile dysfunction (ED) and have been marketed since 1998, they cannot restore pathological changes in the penis. Low-energy shock wave therapy (LESWT) has been developed for treating ED, and clinical studies have shown that LESWT has the potential to affect PDE5I non-responders with ED with few adverse effects. Animal studies have shown that LESWT significantly improves penile hemodynamics and restores pathological changes in the penis of diabetic ED animal models. Although the mechanisms remain to be investigated, recent studies have reported that LESWT could partially restore corpus cavernosum fibromuscular pathological changes, endothelial dysfunction, and peripheral neuropathy. LESWT could be a novel modality for treating ED, and particularly PDE5I non-responders with organic ED, in the near future. However, further extensive evidence-based basic and clinical studies are needed. This review intends to summarize the scientific background underlying the effect of LESWT on ED.
