A Case of Idiopathic Hypereosinophilic Syndrome Treated Successfully with Hydroxyurea and Interferon alpha-2b.
- Author:
Gi Hoon YANG
1
;
Eun Young PARK
;
Hye Lim JUNG
;
Deok Soo KIM
;
Jae Won SHIM
;
Jung Yeon SHIM
;
Moon Soo PARK
Author Information
1. Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. jungped@samsung.co.kr
- Publication Type:Case Report
- Keywords:
Idiopathic hypereosinophilic syndrome;
Hydroxyurea;
Interferon alpha-2b
- MeSH:
Bone Marrow;
Brain;
Diagnosis;
Eosinophilia;
Eosinophils;
Heart;
Humans;
Hydroxyurea*;
Hypereosinophilic Syndrome*;
Infant;
Interferons*;
Lung;
Male;
Prednisolone;
Spleen
- From:Korean Journal of Pediatric Hematology-Oncology
2003;10(2):269-276
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The idiopathic hypereosinophilic syndromes are rare hematologic disorders showing a wide spectrum of diseases with eosinophilia and associated organ damage. Three criteria for diagnosis include persistent eosinophilia of at least 1, 500 eosinophils/mm3 for longer than 6 months, or death before 6 months with signs and symptoms of hypereosinophilic disease; lack of evidence for parasitic, allergic or other known causes of eosinophilia; and signs and symptoms of organ involvement. We report a case of a 8 month-old male patient who had persistent marked eosinophilia reaching peak eosinophil count more than 100, 000/mm3, and organ dysfunction involving the bone marrow, heart, brain, lung and spleen. This patient, who did not respond to administration of prednisolone or hydroxyurea alone, has been treated successfully with hydroxyurea and interferon alpha-2b combination therapy.
