Three Cases of Childhood Renal Cell Carcinoma Including 2 Cases with Systemic Immunotherapy.
- Author:
Hye Rim CHUNG
1
;
Eun Sil PARK
;
Hyoung Soo CHOI
;
Hee Young SHIN
;
Hyo Seop AHN
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. hsahn@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Renal cell carcinoma;
Immumotherapy;
Childhood
- MeSH:
Adult;
Carcinoma, Renal Cell*;
Child;
Diagnosis;
Disease Progression;
Drug Therapy;
Epithelial Cells;
Humans;
Immunotherapy*;
Incidence;
Interferon-alpha;
Interleukin-2;
Lymph Node Excision;
Neoplasm Metastasis;
Nephrectomy;
Radiotherapy;
Rare Diseases
- From:Korean Journal of Pediatric Hematology-Oncology
2003;10(2):287-292
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Renal cell carcinoma (RCC) is a malignancy arising from the tubular epithelial cell. RCC is a rare disease in children with an incidence of 0.1~0.3% of all childhood cancer. It is known that RCC in children is different from its adult counterpart in some aspects. Although conventional treatment of RCC is radical nephrectomy with lymph node dissection, we tried systemic treatment for advanced disease. Because metastasis is common at diagnosis and RCC is usually resistant to radiotherapy or chemotherapy, immunotherapy such as interferon-alpha (IFN-alpha) or interleukin-2 (IL-2) is investigated and clinically used. We have experienced 3 children with RCC and two with stage IV disease were treated with systemic immunotherapy. One who had stage IV, recurred RCC is followed-up for 16 months without the evidence of disease progression with IFN-alpha and IL-2. We report these 3 cases with a brief review of literatures.
