Associations between serum 25-hydroxyvitamin D3 level and skeletal muscle mass and lower limb muscle strength in Japanese middle-aged subjects.
10.1016/j.afos.2017.02.002
- Author:
Akiko KUWABARA
1
;
Naoko TSUGAWA
;
Hiroshi KONDO
;
Misora AO
;
Hitomi FUJIWARA
;
Natsuki HOSOKAWA
;
Shiho MATSUMOTO
;
Kiyoshi TANAKA
;
Tetsuo NAKANO
Author Information
1. Department of Health and Nutrition, Osaka Shoin Women's University, 4-2-26 Hishiyanishi, Higashiosaka, Osaka 577-8550, Japan. kuwabara.akiko@osaka-shoin.ac.jp
- Publication Type:Original Article
- Keywords:
25-hydoxyvitamin D₃;
24,25-dihydroxyvitamin D₃;
Skeletal muscle mass;
Lower limb muscle strength;
Japanese subjects
- MeSH:
Absorptiometry, Photon;
Accidental Falls;
Adipose Tissue;
Adult;
Asian Continental Ancestry Group*;
Body Composition;
Calcifediol*;
Female;
Healthy Volunteers;
Humans;
Lower Extremity*;
Male;
Motor Activity;
Muscle Strength*;
Muscle, Skeletal*;
Risk Factors;
Vitamin D;
Vitamins
- From:Osteoporosis and Sarcopenia
2017;3(1):53-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: One of the important risk factors of falling is decreased muscle mass and muscle strength. Recently, there has been an increasing concern on the role of vitamin D in muscle strength and physical activity. Aim of our study is to examine the relationships between vitamin D status and muscle mass and muscle strength in middle-aged healthy adults. METHODS: Subjects were 40 healthy volunteers aged 42.0 ± 10.6 years old. Evaluation was made for serum vitamin D₃ metabolites including 25-hydroxyvitamin D₃ [25(OH)D₃] and 24,25-dihydroxyvitamin D₃ [24,25(OH)₂D₃] concentrations, lower limb muscle strength, and dietary intake by food frequency questionnaire. Body composition was measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal mass index (ASMI) was calculated as skeletal muscle mass/squared height. RESULTS: 70% of the subjects had vitamin D insufficiency/deficiency (serum total 25(OH)D < 20 ng/mL), and female subjects had significantly lower serum total 25(OH)D level compared with males. Vitamin D insufficiency/deficiency group had significantly higher body fat, lower SMI and muscle strength, probably reflecting higher percentage of female subjects. Serum vitamin D₃ metabolites levels were significantly correlated with whole and site-specific ASMI, and lower limb muscle strength, except for the correlation between serum 24,25(OH)₂D₃ concentration and lower limb muscle strength. In addition, serum 25(OH)D₃ level was a positive significant predictor for both ASMI and lower limb muscle strength, while serum 24,25(OH)₂D₃ level was not their significant predictor. CONCLUSIONS: Serum 25(OH)D₃ level was significantly correlated with both skeletal muscle mass and lower limb muscle strength.
