Efficacy and safety of drospirenone 2 mg/17β-estradiol 1 mg hormone therapy in Korean postmenopausal women.
10.5468/ogs.2017.60.2.213
- Author:
Bo Ra PARK
1
;
Hye Na PARK
;
Ji Back JUNG
;
Eun Sil LEE
;
Jeong Sig KIM
;
Gyu Yeon CHOI
;
Jeong Jae LEE
;
Im Soon LEE
Author Information
1. Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Asan, Korea. eslee165@schmc.ac.kr
- Publication Type:Brief Communication
- Keywords:
Drospirenone;
Effectiveness;
Menopause;
Safety
- MeSH:
Female;
Hormone Replacement Therapy;
Humans;
Incidence;
Mastodynia;
Menopause;
Uterine Hemorrhage
- From:Obstetrics & Gynecology Science
2017;60(2):213-217
- CountryRepublic of Korea
- Language:English
-
Abstract:
This regulatory post-marketing surveillance study aimed to evaluate the therapeutic efficacy and safety of drospirenone (DRSP) 2 mg/estradiol (E₂) 1 mg tablet in Korean postmenopausal women. A total of 4,149 patients were enrolled and the study was conducted at 207 clinical research centers. The patients' source data was collected between November 2006 and November 2012. More than 85% of patients experienced improvement of menopausal symptoms. The most frequently reported adverse events were vaginal bleeding and breast pain; most of the women suffering from these symptoms fully recovered. The incidence of adverse event was higher in patients of younger age (20 to 39 years), in patients with concomitant diseases, previous hormone replacement therapy in medical history, those treated with DRSP 2 mg/E₂ 1 mg for shorter duration (3 years or less) and in patients using concomitant medication. In conclusion, the results from this large post-marketing surveillance study confirm the efficacy and safety of DRSP 2 mg/E₂ 1 mg tablet in Korean postmenopausal women.